Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation.
AuthorsLee JS, Mendez R, Heng HH, Yang ZQ, Zhang K,
JournalAm J Transl Res
PubMed ID22347525
Endoplasmic Reticulum (ER) stress refers to a condition of accumulation of unfolded or misfolded proteins in the ER lumen. A variety of biochemical stimuli or pathophysiologic conditions can directly or indirectly induce ER stress, leading to activation of an ER-originated adaptive signaling response called Unfolded Protein Response (UPR). Recent studies ... More