GDNF family ligand dependent STAT3 activation is mediated by specific alternatively spliced isoforms of GFRa2 and RET.
AuthorsZhou L, Too HP,
Journal
PubMed ID23872421
Neurturin (NRTN), a member of the GDNF family of ligands (GFL), is currently investigated in a series of clinical trials for Parkinson's disease. NRTN signals through its cognate receptor GFRa2 and co-receptor RET to induce neurite outgrowth, but the underlying mechanism remains to be better understood. STAT3 was previously shown ... More