Recognition of nonhybridizing base pairs during nucleotide excision repair of DNA.
AuthorsBuschta-Hedayat N, Buterin T, Hess MT, Missura M, Naegeli H
JournalProc Natl Acad Sci U S A
PubMed ID10339546
Nondistorting C4' backbone adducts serve as molecular tools to analyze the strategy by which a limited number of human nucleotide excision repair (NER) factors recognize an infinite variety of DNA lesions. We have constructed composite DNA substrates containing a noncomplementary site adjacent to a nondistorting C4' adduct to show that ... More