Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements.
AuthorsLee JA, Xing Y, Nguyen D, Xie J, Lee CJ, Black DL,
JournalPLoS Biol
PubMed ID17298178
'Alternative splicing controls the activity of many proteins important for neuronal excitation, but the signal-transduction pathways that affect spliced isoform expression are not well understood. One particularly interesting system of alternative splicing is exon 21 (E21) of the NMDA receptor 1 (NMDAR1 E21), which controls the trafficking of NMDA receptors ... More
Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function.
AuthorsLi Z, Dong T, Pröschel C, Noble M,
JournalPLoS Biol
PubMed ID17298174
Identification of common mechanistic principles that shed light on the action of the many chemically diverse toxicants to which we are exposed is of central importance in understanding how toxicants disrupt normal cellular function and in developing more effective means of protecting against such effects. Of particular importance is identifying ... More