The docking protein FRS2a is a critical regulator of VEGF receptors signaling.
AuthorsChen PY, Qin L, Zhuang ZW, Tellides G, Lax I, Schlessinger J, Simons M,
Journal
PubMed ID24706887
Vascular endothelial growth factors (VEGFs) signal via their cognate receptor tyrosine kinases designated VEGFR1-3. We report that the docking protein fibroblast growth factor receptor substrate 2 (FRS2a) plays a critical role in cell signaling via these receptors. In vitro FRS2a regulates VEGF-A and VEGF-C-dependent activation of extracellular signal-regulated receptor kinase ... More
The important roles of RET, VEGFR2 and the RAF/MEK/ERK pathway in cancer treatment with sorafenib.
AuthorsMao WF, Shao MH, Gao PT, Ma J, Li HJ, Li GL, Han BH, Yuan CG,
JournalActa Pharmacol Sin
PubMed ID22941289
To elucidate the roles of receptor tyrosine kinases RET and VEGFR2 and the RAF/MEK/ERK signaling cascade in cancer treatment with sorafenib. The cell lines A549, HeLa, and HepG2 were tested. The enzyme activity was examined under cell-free conditions using 384-well microplate assays. Cell proliferation was evaluated using the Invitrogen Alarmar ... More