Astroglial connexin immunoreactivity is specifically altered at ß-amyloid plaques in ß-amyloid precursor protein/presenilin1 mice.
AuthorsMei X, Ezan P, Giaume C, Koulakoff A,
JournalNeuroscience
PubMed ID20813165
Activation of astrocytes surrounding amyloid plaques is a hallmark of Alzheimer disease (AD) with consequences yet poorly understood. Astrocytes are characterized by a high level of intercellular communication mediated by two gap-junction forming proteins, connexin-43 and connexin-30. As astroglial connexins (Cxs) are involved in neuronal dysfunctions and death, we have ... More