Insulin enhances growth hormone induction of the MEK/ERK signaling pathway.
AuthorsXu J, Keeton AB, Franklin JL, Li X, Venable DY, Frank SJ, Messina JL,
JournalJ Biol Chem
PubMed ID16272159
'Growth hormone (GH) plays an important role in growth and metabolism by signaling via at least three major pathways, including STATs, ERK1/2, and phosphatidylinositol 3-kinase/Akt. Physiological concentrations of insulin promote growth probably by modulating liver GH receptor (GHR) levels in vivo, but the possible effects of insulin on GH-induced post-GHR ... More