MEKK1 controls neurite regrowth after experimental injury by balancing ERK1/2 and JNK2 signaling.
AuthorsWaetzig V, Herdegen T,
JournalMol Cell Neurosci
PubMed ID16006144
'After injury, peripheral neuronal cells initiate complex signaling cascades to promote survival and regeneration. In the present study, we have identified the mitogen-activated protein kinase (MAPK) isoforms which are necessary for nerve growth factor (NGF)-induced neurite regrowth after injury of differentiated PC12 cells. Extracellular signal-regulated kinases 1 and 2 (ERK1/2) ... More