Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors.
AuthorsChen R, Relouzat F, Roncagalli R, Aoukaty A, Tan R, Latour S, Veillette A,
JournalMol Cell Biol
PubMed ID15169881
2B4 is a SLAM-related receptor expressed on natural killer (NK) cells and cytotoxic T cells. It can regulate killing and gamma interferon secretion by NK cells, as well as T-cell-mediated cytotoxicity. There are conflicting data regarding the mechanism of action of 2B4. In these studies, we attempted to understand better ... More