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Phospho-Tau (Thr217) Polyclonal Antibody

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39 篇参考文献
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Phospho-Tau (Thr217) Polyclonal Antibody

产品信息

44-744

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000
查看19篇已发表文章 19篇已发表文章

免疫组化 (IHC)

-
查看10篇已发表文章 10篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200
查看3篇已发表文章 3篇已发表文章

酶联免疫吸附实验 (ELISA)

-
查看3篇已发表文章 3篇已发表文章

功能检测 (Functional)

-
查看1篇已发表文章 1篇已发表文章

点杂交 (DB)

-
查看1篇已发表文章 1篇已发表文章

其他PubMed (Misc)

-
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产品规格

种属反应

Human, Mouse, Rat

已发表种属

Baboon, Bovine, Dog, Human, Mouse, Non-human primate, Rat, Rhesus monkey, Sheep, Tag

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human tau that contains threonine 217.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

纯化类型

Antigen affinity chromatography

保存液

Dulbecco's PBS, pH 7.3, with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2533741

靶标信息

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: FLJ31424; FTDP17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; MGC138549; Microtubule-associated protein tau; microtubules; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; Paired helical filament-tau; PHF-tau; PHFtau; protein phosphatase 1, regulatory subunit 103; Tau microtubule-associated protein; Tau-4; Tau-derived paired helical filament hexapeptide; Tau5; unnamed protein product

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基因别名: AI413597; AW045860; DDPAC; FTD1; FTDP-17; MAPT; MAPTL; MSTD; Mtapt; MTBT1; MTBT2; PPND; PPP1R103; pTau; RNPTAU; TAU; tau-40; Tau-PHF6

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UniProt ID: (Human) P10636, (Mouse) P10637

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Entrez Gene ID: (Human) 4137, (Rat) 29477, (Mouse) 17762

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功能
DNA binding AT DNA binding double-stranded DNA binding single-stranded DNA binding RNA binding actin binding protein binding microtubule binding tubulin binding SH3 domain binding enzyme binding protein kinase binding protein binding, bridging apolipoprotein binding dynactin binding phosphatidylinositol binding identical protein binding sequence-specific DNA binding chaperone binding protein phosphatase 2A binding Hsp90 protein binding lipoprotein particle binding histone-dependent DNA binding microtubule lateral binding phosphatidylinositol bisphosphate binding protein domain specific binding protein complex binding
参与通路
microtubule cytoskeleton organization microglial cell activation cellular response to DNA damage stimulus cell-cell signaling synapse assembly learning or memory memory response to lead ion regulation of autophagy negative regulation of gene expression negative regulation of mitochondrial membrane potential rRNA metabolic process axonal transport of mitochondrion central nervous system neuron development regulation of microtubule polymerization or depolymerization regulation of microtubule polymerization positive regulation of microtubule polymerization cytoplasmic microtubule organization neuron projection development positive regulation of superoxide anion generation regulation of chromosome organization stress granule assembly cellular response to heat cellular response to reactive oxygen species positive regulation of axon extension microtubule polymerization astrocyte activation regulation of synaptic plasticity intracellular distribution of mitochondria generation of neurons synapse organization regulation of calcium-mediated signaling protein polymerization protein homooligomerization axon development regulation of microtubule cytoskeleton organization plus-end-directed organelle transport along microtubule regulation of mitochondrial fission negative regulation of mitochondrial fission fibril organization axonal transport regulation of cellular response to heat regulation of long term synaptic depression positive regulation of protein localization to synapse neurofibrillary tangle assembly negative regulation of establishment of protein localization to mitochondrion positive regulation of cellular protein localization negative regulation of tubulin deacetylation amyloid fibril formation cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus neuron migration apoptotic process microtubule-based process axonogenesis brain development female pregnancy response to nutrient adult walking behavior axo-dendritic transport intrinsic apoptotic signaling pathway in response to oxidative stress response to organic substance neuron differentiation negative regulation of intracellular transport mitochondrion transport along microtubule axon extension regulation of microtubule-based movement
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