Reducing amyloid-related Alzheimer's disease pathogenesis by a small molecule targeting filamin A.
AuthorsWang HY, Bakshi K, Frankfurt M, Stucky A, Goberdhan M, Shah SM, Burns LH,
JournalJ Neurosci
PubMed ID22815492
PTI-125 is a novel compound demonstrating a promising new approach to treating Alzheimer's disease (AD), characterized by neurodegeneration and amyloid plaque and neurofibrillary pathologies. We show that the toxic signaling of amyloid-ß(42) (Aß(42)) by the a7-nicotinic acetylcholine receptor (a7nAChR), which results in tau phosphorylation and formation of neurofibrillary tangles, requires ... More