Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion.
AuthorsSachdev S, Bu Y, Gelman IH,
JournalBMC Cancer
PubMed ID19138410
'Focal adhesion kinase (FAK) and Src are protein tyrosine kinases that physically and functionally interact to facilitate cancer progression by regulating oncogenic processes such as cell motility, survival, proliferation, invasiveness, and angiogenesis. To understand how FAK affects oncogenesis through the phosphorylation of cellular substrates of Src, we analyzed the phosphorylation ... More
Insulin enhances growth hormone induction of the MEK/ERK signaling pathway.
AuthorsXu J, Keeton AB, Franklin JL, Li X, Venable DY, Frank SJ, Messina JL,
JournalJ Biol Chem
PubMed ID16272159
'Growth hormone (GH) plays an important role in growth and metabolism by signaling via at least three major pathways, including STATs, ERK1/2, and phosphatidylinositol 3-kinase/Akt. Physiological concentrations of insulin promote growth probably by modulating liver GH receptor (GHR) levels in vivo, but the possible effects of insulin on GH-induced post-GHR ... More
Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data.
AuthorsChen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK,
JournalMol Syst Biol
PubMed ID19156131
The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, it remains poorly understood how different ligands induce different responses and how this is affected by oncogenic mutations. To quantify signal flow through ErbB-activated pathways we ... More