Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton.
AuthorsHead JA, Jiang D, Li M, Zorn LJ, Schaefer EM, Parsons JT, Weed SA,
JournalMol Biol Cell
PubMed ID12925758
Cortactin is an F-actin binding protein that activates actin-related protein 2/3 complex and is localized within lamellipodia. Cortactin is a substrate for Src and other protein tyrosine kinases involved in cell motility, where its phosphorylation on tyrosines 421, 466, and 482 in the carboxy terminus is required for cell movement ... More