Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain.
AuthorsFeire AL, Koss H, Compton T,
JournalProc Natl Acad Sci U S A
PubMed ID15494436
Human cytomegalovirus (HCMV) is capable of manifesting disease in nearly every organ system in immunocompromised patients. This broad pathogenic tropism correlates with the ability of the virus to infect all tested vertebrate cell types in vitro, a characteristic that has made receptor identification extremely difficult. During virus entry, HCMV induces ... More
Focal complex formation in adult cardiomyocytes is accompanied by the activation of beta3 integrin and c-Src.
In pressure-overloaded myocardium, our recent study demonstrated cytoskeletal assembly of c-Src and other signaling proteins which was partially mimicked in vitro using adult feline cardiomyocytes embedded in three-dimensional (3D) collagen matrix and stimulated with an integrin-binding Arg-Gly-Asp (RGD) peptide. In the present study, we improved this model further to activate ... More