Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC.
AuthorsSeki T, Matsubayashi H, Amano T, Shirai Y, Saito N, Sakai N,
JournalGenes Cells
PubMed ID15743412
'Protein kinase C (PKC) is translocated to various cellular regions in a subtype and stimulation-dependent manner. Thereafter, the activated PKC phosphorylates its substrate and causes subsequent cellular responses (PKC targeting). The 3-phosphoinositide-dependent protein kinase-1 (PDK1) has an essential role in the maturation of PKC by phosphorylating a threonine residue in ... More