Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.
Authors Lee Hahn-Jun; Jung Kwang-Mook; Huang Yang Z; Bennett Lori B; Lee Joanne S; Mei Lin; Kim Tae-Wan;
JournalJ Biol Chem
PubMed ID11741961
An unusual protease gamma-secretase requires functional presenilins and cleaves substrates (e.g. amyloid beta-protein precursor and Notch) with very loose amino acid sequence specificity within the transmembrane region. Here we report that ErbB4, a tyrosine kinase receptor for neuregulins, is a substrate for presenilin-dependent gamma-secretase. Our studies show that constitutive ectodomain ... More