Isolation and sequence analysis of the cDNA for pig kidney fructose 1,6- bisphosphatase.
AuthorsWilliams MK, Kantrowitz ER
JournalProc Natl Acad Sci U S A
PubMed ID1313579
'A full-length clone of pig kidney fructose 1,6-bisphosphatase (D- fructose-1,6-bisphosphate 1-phosphohydrolase, EC 3.1.3.11) was isolated by screening a cDNA library for complementation of an Escherichia coli fbp deletion mutation. The open reading frame of 1011 bases corresponds to 337 amino acids, two more than have been previously reported [Marcus, F., ... More
Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum.
AuthorsLombroso PJ, Murdoch G, Lerner M
JournalProc Natl Acad Sci U S A
PubMed ID1714595
A cDNA clone encoding a neural-specific putative protein-tyrosine- phosphatase (protein-tyrosine-phosphate phosphohydrolase, EC 3.1.3.48) has been isolated from a rat striatal cDNA library. The deduced amino acid sequence predicts a protein of approximately 369 amino acids with a strong homology to other members of the family of protein-tyrosine- phosphatases. In vitro ... More
Expression of bitter taste receptors of the T2R family in the gastrointestinal tract and enteroendocrine STC-1 cells.
Authors Wu S Vincent; Rozengurt Nora; Yang Moon; Young Steven H; Sinnett-Smith James; Rozengurt Enrique;
JournalProc Natl Acad Sci U S A
PubMed ID11854532
Although a role for the gastric and intestinal mucosa in molecular sensing has been known for decades, the initial molecular recognition events that sense the chemical composition of the luminal contents has remained elusive. Here we identified putative taste receptor gene transcripts in the gastrointestinal tract. Our results, using reverse ... More