Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis.
Authors:Jarolim P, Palek J, Amato D, Hassan K, Sapak P, Nurse GT, Rubin HL, Zhai S, Sahr KE, Liu SC
Journal:Proc Natl Acad Sci U S A
PubMed ID:1722314
Southeast Asian ovalocytosis (SAO) is a hereditary condition that is widespread in parts of Southeast Asia. The ovalocytic erythrocytes are rigid and resistant to invasion by various malarial parasites. We have previously found that the underlying defect in SAO involves band 3 protein, the major transmembrane protein, which has abnormal ... More