Profound alteration in an alpha beta T-cell antigen receptor repertoire due to polymorphism in the first complementarity-determining region of the beta chain.
AuthorsGahm SJ, Fowlkes BJ, Jameson SC, Gascoigne NR, Cotterman MM, Kanagawa O, Schwartz RH, Matis LA
JournalProc Natl Acad Sci U S A
PubMed ID1835090
'Amino acid residues that are critical in maintaining the framework structure of immunoglobulin heavy- and light-chain variable (V) regions are strongly conserved in the V alpha and V beta proteins of the alpha beta T-cell antigen receptor (TCR alpha beta). Consequently, it has been proposed that TCR alpha beta has ... More