Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease.
AuthorsHe P, Shen Y,
JournalJ Neurosci
PubMed ID19458225
'The neuronal loss associated with Alzheimer''s disease (AD) affects areas of the brain that are vital to cognition. Although recent studies have shown that new neurons can be generated from progenitor cells in the neocortices of healthy adults, the neurogenic potential of the stem/progenitor cells of AD patients is not ... More
Zona occludens-2 protects against podocyte dysfunction induced by ADR in mice.
AuthorsBautista-García P, Reyes JL, Martín D, Namorado MC, Chavez-Munguía B, Soria-Castro E, Huber O, González-Mariscal L,
JournalAm J Physiol Renal Physiol
PubMed ID23034938
Zona occludens-2 (ZO-2) is a protein present at the tight junction and nucleus of epithelial cells. ZO-2 represses the transcription of genes regulated by the Wnt/ß-catenin pathway. This pathway plays a critical role in podocyte injury and proteinuria. Here, we analyze whether the overexpression of ZO-2 in the glomerulus, by ... More