Heightened inflammasome activation is linked to age-related cognitive impairment in Fischer 344 rats.
AuthorsMawhinney LJ, de Rivero Vaccari JP, Dale GA, Keane RW, Bramlett HM,
JournalBMC Neurosci
PubMed ID22133203
'Members of the mammalian nucleotide binding domain, leucine-rich repeat (LRR)-containing receptor (NLR) family of proteins are key modulators of innate immunity regulating inflammation. Our previous work has shown that among the members of this family, NLRP1/NALP1, present in neurons, plays a crucial role in inflammasome formation and the production of ... More