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Invitrogen
Smooth Muscle Myosin Monoclonal Antibody (SMMS-1), eFluor™ 660, eBioscience™
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图: 1 / 1
Smooth Muscle Myosin Antibody (50-6400-80) in IHC (P)
Immunohistochemistry of formalin-fixed paraffin embedded human infiltrating ductal carcinoma, using 20 µg/mL of Mouse IgG1 K Isotype Control eFluor® 660 (left) or 20 µg/mL of Anti-Smooth Muscle Myosin eFluor® 660 (right). Nuclei are stained with DAPI.
产品信息
50-6400-80
产品规格
种属反应
Bovine,
Dog,
Cat,
Human,
Rat
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
SMMS-1
偶联物
eFluor™ 660
eFluor™ 660
eFluor™ 660
激发/发射光谱
651/668 nm
查看光谱
形式
Liquid
浓度
0.2 mg/mL
规格
25 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Description: This SMMS-1 monoclonal antibody reacts with both isoforms of the human smooth muscle myosin heavy chain (SM1 and SM2) structural proteins, which are components of the contractile apparatus in smooth muscle cells. Smooth muscle myosin heavy chains are expressed by myoepithelial cells and also serve as the terminal differentiation marker for smooth muscle cells. In normal breast tissue, myoepithelial cells compose the outer layer of the lumen lining. In benign and in situ breast lesions, the intact myoepithelial layer stains with SMMS-1 and the loss of this staining indicates invasive cancer. This SMMS-1 antibody has also been reported to cross-react with bovine, canine, feline, and rat smooth muscle myosin heavy chains.
Applications Reported: This SMMS-1 antibody has been reported for use in microscopy, immunohistochemical staining of frozen and formalin-fixed paraffin embedded tissue sections, and immunocytochemistry.
Applications Tested: This SMMS-1 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low pH antigen retrieval at less than or equal to 20 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.
eFluor™ 660 is a replacement for Alexa Fluor™ 647. eFluor™ 660 emits at 659 nm and is excited with the red laser (633 nm). Please make sure that your instrument is capable of detecting this fluorochome.
Excitation: 633-647 nm; Emission: 668 nm; Laser: Red Laser.
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
SM-MHC is a cytoplasmic structural protein, which is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmently regulated, appearing early in smooth muscle development, and is specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: contractile protein; epididymis secretory sperm binding protein; myh11 {ECO:0000312|RGD:3136}; Myosin heavy chain 11; myosin heavy chain 21; myosin heavy chain SMA; Myosin heavy chain, smooth muscle isoform; myosin transcript variant (+) insert SM1; myosin transcript variant (+) insert SM2; myosin, heavy chain 11, smooth muscle; myosin, heavy polypeptide 11, smooth muscle; Myosin-11; SMMHC; smooth muscle myosin heavy chain
基因别名: AAT4; FAA4; KIAA0866; MYH11; SMHC; SMMHC; SMMS-1; VSCM2
UniProt ID: (Human) P35749
Entrez Gene ID: (Bovine) 530050, (Human) 4629, (Dog) 479836, (Rat) 24582
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