HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses.
AuthorsTomko RP, Xu R, Philipson L
JournalProc Natl Acad Sci U S A
PubMed ID9096397
'The subgroup C of the adenoviruses (Ad) and the group B coxsackieviruses (CVB) are structurally unrelated viruses that are known to compete for an unidentified cell surface receptor. We now describe the isolation of cDNAs from human and mouse that encode the human CVB and Ad2 and 5 receptor (HCAR) ... More
The coxsackie- and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis.
'The coxsackie- and adenovirus receptor (CAR) is a transmembrane protein belonging to the immunoglobulin superfamily. The function of CAR as a virus receptor has been extensively analyzed, while its physiological role and expression pattern in adult tissues have remained less clear. CAR associates with epithelial tight junctions in vitro and ... More
Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution.
Authorsvan Raaij MJ, Chouin E, van der Zandt H, Bergelson JM, Cusack S
JournalStructure
PubMed ID11080637
The coxsackievirus and adenovirus receptor (CAR) comprises two extracellular immunoglobulin domains, a transmembrane helix and a C-terminal intracellular domain. The amino-terminal immunoglobulin domain (D1) of CAR is necessary and sufficient for adenovirus binding, whereas the site of coxsackievirus attachment has not yet been localized. The normal cellular role of CAR ... More
The coxsackie-adenovirus receptor--a new receptor in the immunoglobulin family involved in cell adhesion.
AuthorsPhilipson L, Pettersson RF
JournalCurr Top Microbiol Immunol
PubMed ID14674599
The physiological and cell biological aspects of the Coxsackie-Adenovirus Receptor (CAR) is discussed in this review. The receptor obviously recognizes the group C adenoviruses in vivo, but also fibers from other groups except group B in vitro. The latter viruses seem to utilize a different receptor. The receptor accumulates at, ... More
Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism.
AuthorsSelinka HC, Wolde A, Sauter M, Kandolf R, Klingel K
JournalMed Microbiol Immunol
PubMed ID12920584
Specific virus-receptor interactions are important determinants in the pathogenesis of viral infections, influencing the location and initiation of primary infection as well as the viral spread to other target organs in the postviremic phase. Coxsackieviruses of group B (CVB) specifically interact with at least two receptor proteins, the coxsackievirus-adenovirus receptor ... More
Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting.
AuthorsCohen CJ, Gaetz J, Ohman T, Bergelson JM
JournalJ Biol Chem
PubMed ID11316797
The coxsackievirus and adenovirus receptor (CAR) mediates attachment and infection by coxsackie B viruses and many adenoviruses. In human airway epithelia, as well as in transfected Madin-Darby canine kidney cells, CAR is expressed exclusively on the basolateral surface. Variants of CAR that lack the cytoplasmic domain or are attached to ... More
Receptor for the group B coxsackieviruses and adenoviruses: CAR.
AuthorsCarson SD
JournalRev Med Virol
PubMed ID11479928
Considerable progress towards the characterisation of the long-sought receptor, CAR (coxsackievirus and adenovirus receptor), shared by group B coxsackieviruses (CVB) and most adenoviruses (Ad) has been made since it was isolated and cloned in 1997. The primary sequence of CAR shows that it is a member of the immunoglobulin superfamily ... More