CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development.
AuthorsGravestein LA, van Ewijk W, Ossendorp F, Borst J
JournalJ Exp Med
PubMed ID8760821
'CD27 is a lymphocyte-specific member of the TNF receptor family and has a TNF-related transmembrane ligand, CD70. The CD27/CD70 receptor-ligand pair cooperates with the TCR in the regulation of the peripheral T cell response. The study presented here reveals that CD27 may play a similar role in thymic pre-T cell ... More
CD27 and CD70 in T cell and B cell activation.
AuthorsBorst J, Hendriks J, Xiao Y
JournalCurr Opin Immunol
PubMed ID15886117
In vitro work has defined the TNF receptor family member CD27 as a T and B cell co-stimulatory molecule. Its activity is governed by the transient availability of its TNF-like ligand CD70 on lymphocytes and dendritic cells. Recent studies, enforcing or abrogating CD27 function by genetic or protein intervention in ... More
Expression of CD27 on murine hematopoietic stem and progenitor cells.
AuthorsWiesmann A, Phillips RL, Mojica M, Pierce LJ, Searles AE, Spangrude GJ, Lemischka I
JournalImmunity
PubMed ID10714685
Hematopoietic stem cells (HSC) are defined by self-renewal and multilineage differentiation potentials. In order to uncover the genetic program of HSC, we utilized high-density arrays to compare gene expression in highly purified mouse HSC and their mature progeny. One molecule specifically expressed in immature cells is CD27, a member of ... More
CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein.
AuthorsPrasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF
JournalProc Natl Acad Sci U S A
PubMed ID9177220
Members of the tumor necrosis factor receptor (TNFR) superfamily are important for cell growth and survival. In addition to providing costimulatory signals for cell proliferation, ligation of both TNFR1 and Fas can result in programmed cell death or apoptosis. The underlying mechanism requires an intact 80-aa stretch present in the ... More
CD27 is acquired by primed B cells at the centroblast stage and promotes germinal center formation.
AuthorsXiao Y, Hendriks J, Langerak P, Jacobs H, Borst J
JournalJ Immunol
PubMed ID15187121
Studies on human B cells have featured CD27 as a marker and mediator of the B cell response. We have studied CD27 expression and function on B cells in the mouse. We find that B cells acquire CD27 at the centroblast stage and lose it progressively upon further differentiation. It ... More
Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family.
AuthorsGravestein LA, Blom B, Nolten LA, de Vries E, van der Horst G, Ossendorp F, Borst J, Loenen WA
JournalEur J Immunol
PubMed ID8384562
CD27 is a member of the nerve growth factor receptor family, that includes two types of tumor necrosis factor receptor, CD40 and Fas/Apo-1. Human CD27 has been found only on lymphocytes. In T cells, its expression strongly increases in a transient fashion upon antigenic stimulation, suggesting that CD27 plays a ... More