Human CD38: a (r)evolutionary story of enzymes and receptors.
AuthorsDeaglio S, Mehta K, Malavasi F
JournalLeuk Res
PubMed ID11137554
'Human CD38 is the mammalian prototype of a family of proteins which share structural similarities and an ectoenzymatic activity involved in the production of calcium mobilizing compounds. Besides the enzymatic activity, the molecule performs as a receptor, ruling adhesion and signaling in leukocytes. These functions are exerted through the interaction ... More
CD38 as a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions.
AuthorsChini EN
JournalCurr Pharm Des
PubMed ID19149603
'CD38 is a multifunctional enzyme that uses nicotinamide adenine dinucleotide (NAD) as a substrate to generate second messengers. Recently, CD38 was also identified as one of the main cellular NADases in mammalian tissues and appears to regulate cellular levels of NAD in multiple tissues and cells. Due to the emerging ... More
CD38 is critical for social behaviour by regulating oxytocin secretion.
AuthorsJin D, Liu HX, Hirai H, Torashima T, Nagai T, Lopatina O, Shnayder NA, Yamada K, Noda M, Seike T, Fujita K, Takasawa S, Yokoyama S, Koizumi K, Shiraishi Y, Tanaka S, Hashii M, Yoshihara T, Higashida K, Islam MS, Yamada N, Hayashi K, Noguchi N, Kato I, Okamoto H, Matsushima A, Salmina A, Munesue T, Shimizu N, Mochida S, Asano M, Higashida H
JournalNature
PubMed ID17287729
CD38, a transmembrane glycoprotein with ADP-ribosyl cyclase activity, catalyses the formation of Ca2+ signalling molecules, but its role in the neuroendocrine system is unknown. Here we show that adult CD38 knockout (CD38-/-) female and male mice show marked defects in maternal nurturing and social behaviour, respectively, with higher locomotor activity. ... More
CD38 is constitutively expressed in the nucleus of human hematopoietic cells.
AuthorsOrciani M, Trubiani O, Guarnieri S, Ferrero E, Di Primio R
JournalJ Cell Biochem
PubMed ID18759251
CD38 is a type II glycoprotein that acts both as a bifunctional enzyme, responsible for the synthesis and hydrolysis of cyclic ADP-ribose, and as a signal-transducing surface receptor. Although CD38 was originally described as a plasma membrane molecule, several reports indicate that CD38 is expressed in the nucleus, even in ... More
Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology.
AuthorsMalavasi F, Deaglio S, Funaro A, Ferrero E, Horenstein AL, Ortolan E, Vaisitti T, Aydin S
JournalPhysiol Rev
PubMed ID18626062
The membrane proteins CD38 and CD157 belong to an evolutionarily conserved family of enzymes that play crucial roles in human physiology. Expressed in distinct patterns in most tissues, CD38 (and CD157) cleaves NAD(+) and NADP(+), generating cyclic ADP ribose (cADPR), NAADP, and ADPR. These reaction products are essential for the ... More