Increase of CD5(+) B cells during adolescence in female mice.
AuthorsWatanabe K, Watanabe M, Maruoka H, Amino N, Iwatani Y
JournalMech Ageing Dev
PubMed ID11557280
We examined physiological changes in CD5(+) B lymphocytes in mice associated with aging (from 1 or 5 to 50 weeks of age). The most predominant populations of lymphocytes among these mice were mainly CD5(-) B cells in the spleen and peritoneal cavity, and T cells in the thymus. However, in ... More
CD5: a safeguard against autoimmunity and a shield for cancer cells.
AuthorsDalloul A
JournalAutoimmun Rev
PubMed ID19041428
CD5 is a pan T cell marker also expressed at various developmental and activation stages on human B cells. CD5 is a well established negative regulator of TCR and BCR signalling. In the last years, great advances have been made in understanding the molecular mechanisms behind this regulatory function. Using ... More
Characterization of rabbit CD5 isoforms.
AuthorsPospisil R, Kabat J, Mage RG
JournalMol Immunol
PubMed ID19520434
Previously described polyclonal or monoclonal antibodies (mAb) to rabbit CD5, raised against expressed recombinant protein or peptides, recognize CD5 on most rabbit B cells. The mAb KEN-5 was originally reported to recognize rabbit CD5. However, KEN-5 binds almost exclusively to T cells and only to a minor population of B ... More