The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway.
AuthorsNoren NK, Foos G, Hauser CA, Pasquale EB
JournalNat Cell Biol
PubMed ID16862147
'Recent evidence supports a role for EphB receptor tyrosine kinases as tumour suppressors in colorectal and prostate cancer. However, it is unclear how these receptors inhibit cancer cell tumorigenicity - an activity that is highly unusual for a family of receptor tyrosine kinases. Here, we report that the EphB4 receptor ... More
The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth.
The receptor tyrosine kinase EphB4 and its ligand EphrinB2 play a crucial role in vascular development during embryogenesis. The soluble monomeric derivative of the extracellular domain of EphB4 (sEphB4) was designed as an antagonist of EphB4/EphrinB2 signaling. sEphB4 blocks activation of EphB4 and EphrinB2; suppresses endothelial cell migration, adhesion, and ... More
'Eph'ective signaling: forward, reverse and crosstalk.
AuthorsMurai KK, Pasquale EB
JournalJ Cell Sci
PubMed ID12808016
The Eph receptors comprise the largest group of receptor tyrosine kinases and are found in a wide variety of cell types in developing and mature tissues. Their ligands are the ephrins, a family of membrane-bound proteins found in lipid rafts. In the past decade, Eph receptors and ephrins have been ... More
Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth.
AuthorsNoren NK, Lu M, Freeman AL, Koolpe M, Pasquale EB
JournalProc Natl Acad Sci U S A
PubMed ID15067119
Receptor tyrosine kinases of the Eph family are up-regulated in different types of cancer. EphB4 and its ligand ephrin-B2 have been linked to breast cancer, but little is known about how this receptor-ligand complex may contribute to oncogenesis. The Eph receptors transmit forward signals via their kinase domain and reverse ... More
Cloning and characterization of HTK, a novel transmembrane tyrosine kinase of the EPH subfamily.
AuthorsBennett BD, Wang Z, Kuang WJ, Wang A, Groopman JE, Goeddel DV, Scadden DT
JournalJ Biol Chem
PubMed ID8188704
Using a polymerase chain reaction based strategy, we identified a novel transmembrane tyrosine kinase in CD34+ human bone marrow cells and a human hepatocellular carcinoma cell line, Hep3B. This protein, hepatoma transmembrane kinase or Htk, shares amino acid similarity with the EPH subfamily of tyrosine kinases. The HTK gene is ... More
EphB4 expression and biological significance in prostate cancer.
Prostate cancer is the most common cancer in men. Advanced prostate cancer spreading beyond the gland is incurable. Identifying factors that regulate the spread of tumor into the regional nodes and distant sites would guide the development of novel diagnostic, prognostic, and therapeutic targets. The aim of our study was ... More