How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration.
AuthorsZhou A, Huntington JA, Pannu NS, Carrell RW, Read RJ
JournalNat Struct Biol
PubMed ID12808446
'The interaction of the plasma protein vitronectin with plasminogen activator inhibitor-1 (PAI-1) is central to human health. Vitronectin binding extends the lifetime of active PAI-1, which controls hemostasis by inhibiting fibrinolysis and has also been implicated in angiogenesis. The PAI-1-vitronectin binding interaction also affects cell adhesion and motility. For these ... More
Role of vitronectin and its receptors in haemostasis and vascular remodeling.
AuthorsPreissner KT, Seiffert D
JournalThromb Res
PubMed ID9610756
Vitronectin and its receptors.
AuthorsFelding-Habermann B, Cheresh DA
JournalCurr Opin Cell Biol
PubMed ID7694604
The extracellular matrix protein vitronectin is recognized as an adhesive substrate by cells expressing at least one of four known vitronectin receptors: integrins alpha v beta 1, alpha v beta 3, alpha v beta 5 or alpha IIb beta 3. Cell interaction with vitronectin may induce spreading and migration and ... More
Nucleotide sequence and organization of the human S-protein gene: repeating peptide motifs in the "pexin" family and a model for their evolution.
AuthorsJenne D, Stanley KK
JournalBiochemistry
PubMed ID2447940
The S-protein/vitronectin gene was isolated from a human genomic DNA library, and its sequence of about 5.3 kilobases including the adjacent 5' and 3' flanking regions was established. Alignment of the genomic DNA nucleotide sequence and the cDNA sequence indicated that the gene consisted of eight exons and seven introns. ... More