A novel anti-human syndecan-1 (CD138) monoclonal antibody 4B3: characterization and application.
AuthorsSun WP, Wang FM, Xie F, Wang GQ, Sun J, Yu GH, Qiu YH, Zhang XG
JournalCell Mol Immunol
PubMed ID17601375
'Syndecan-1 (CD138), a member of integral membrane heparin sulfate proteoglycans, is an essential matrix receptor for maintaining the normal morphological phenotypes. In this study, we generated a specific mouse anti-human syndecan-1 monoclonal antibody (mAb) 4B3 and identified it by competition assay with the available syndecan-1 mAb (BB4). Stained by 4B3, ... More
CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms.
AuthorsO'Connell FP, Pinkus JL, Pinkus GS
JournalAm J Clin Pathol
PubMed ID14983940
'We evaluated the immunohistochemical profile and specificity of CD138 reactivity in 238 specimens from hematopoietic and nonhematopoietic neoplasms. In 91 bone marrow biopsies, CD138 reactivity was observed for nonneoplastic plasma cells, neoplastic plasma cells in multiple myeloma cases (43/43), and the plasmacytic component in lymphoplasmacytic lymphoma cases (4/4). Stromal reactivity ... More
Syndecan 1 (CD138) serum levels: a novel biomarker in predicting liver fibrosis stage in patients with hepatitis C.
AuthorsZvibel I, Halfon P, Fishman S, Penaranda G, Leshno M, Or AB, Halpern Z, Oren R
JournalLiver Int
PubMed ID18694404
'Syndecan 1 (CD 138) is a cell surface proteoglycan shed by cells in several pathological conditions, including wound healing. The aim of this study was to test whether CD138 could serve as a non-invasive marker for detection of liver fibrosis and thereby reduce the need for liver biopsy.' ... More
Expression of CD138 (Syndecan-1) in renal cell carcinoma is reduced with increasing nuclear grade.
AuthorsGökden N, Greene GF, Bayer-Garner IB, Spencer HJ, Sanderson RD, Gökden M
JournalAppl Immunohistochem Mol Morphol
PubMed ID16785785
'CD138/Syndecan-1 is a cell-surface heparan sulfate proteoglycan expressed on most epithelial cells, and decreased CD138 expression is associated with increased invasive and metastatic potential in carcinomas. CD138 expression has not been investigated previously in renal neoplasms. Formalin-fixed, paraffin-embedded tissue sections of 50 renal cell carcinomas (RCCs) (40 clear-cell RCCs of ... More
Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma.
AuthorsShimada K, Nakamura M, De Velasco MA, Tanaka M, Ouji Y, Miyake M, Fujimoto K, Hirao K, Konishi N
JournalCancer Sci
PubMed ID19860843
'Heparan sulfate proteoglycan syndecan-1, CD138, is well known to be associated with cell proliferation, adhesion, and migration in various types of malignancies. In the present study, we focused on the role of syndecan-1 in human urothelial carcinoma of the urinary bladder. Silencing of syndecan-1 by siRNA transfection down-regulated transcriptional factor ... More