A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions.
AuthorsMarambaud P, Shioi J, Serban G, Georgakopoulos A, Sarner S, Nagy V, Baki L, Wen P, Efthimiopoulos S, Shao Z, Wisniewski T, Robakis NK
JournalEMBO J
PubMed ID11953314
'E-cadherin controls a wide array of cellular behaviors including cell-cell adhesion, differentiation and tissue development. Here we show that presenilin-1 (PS1), a protein involved in Alzheimer''s disease, controls a gamma-secretase-like cleavage of E-cadherin. This cleavage is stimulated by apoptosis or calcium influx and occurs between human E-cadherin residues Leu731 and ... More
Cloning and characterization of the human invasion suppressor gene E-cadherin (CDH1).
AuthorsBerx G, Staes K, van Hengel J, Molemans F, Bussemakers MJ, van Bokhoven A, van Roy F
JournalGenomics
PubMed ID7601454
E-cadherin is a Ca(2+)-dependent epithelial cell-cell adhesion molecule. Downregulation of E-cadherin expression often correlates with strong invasive potential and poor prognosis of human carcinomas. By using recombinant lambda phage, cosmid, and P1 phage clones, we isolated the full-length human E-cadherin gene (CDH1). The gene spans a region of approximately 100 ... More
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.
AuthorsYoshiura K, Kanai Y, Ochiai A, Shimoyama Y, Sugimura T, Hirohashi S
JournalProc Natl Acad Sci U S A
PubMed ID7543680
E-Cadherin, a cell adhesion molecule, which plays a key role in maintaining the epithelial phenotype, is regarded as an invasion-suppressor gene in light of accumulating evidence from in vitro experiments and clinical observations. In an attempt to clarify the mechanism responsible for inactivation of this gene in carcinomas, we investigated ... More
E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.
AuthorsBecker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR, Höfler H
JournalCancer Res
PubMed ID8033105
The calcium-dependent homophilic cell adhesion molecule and candidate suppressor gene, E (epithelial)-cadherin, plays a major role in the organization and integrity of most epithelial tissues. Diffusely growing gastric carcinomas show markedly reduced homophilic cell-to-cell interactions. We speculated that mutations in the E-cadherin gene may be responsible for the scattered phenotype ... More