Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory.
AuthorsWood MA, Kaplan MP, Brensinger CM, Guo W, Abel T
JournalHippocampus
PubMed ID15884048
'Regulated proteolysis by the ubiquitin pathway has been implicated in control of the cell cycle, transcriptional activation, cell fate and growth, and synaptogenesis. The ubiquitin-proteasome system is involved in synaptic plasticity and is proposed to be part of a molecular switch that converts short-term synaptic potentiation to long-term changes in ... More
Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses.
AuthorsSetsuie R, Suzuki M, Tsuchiya Y, Wada K
JournalNeurochem Int
PubMed ID20380862
'Ubiquitin C-terminal hydrolase (UCH)-L3 is an enzyme with a strongly suggested de-ubiquitinating function by in vitro studies, but has poorly been investigated in vivo. In this study, we show that skeletal muscles of Uchl3(-/-) mice exhibit the up-regulation of cleaved ATF6, Grp78, and PDI as well as HSP27, HSP70, HSP90 ... More
Ubiquitin dimers control the hydrolase activity of UCH-L3.
AuthorsSetsuie R, Sakurai M, Sakaguchi Y, Wada K
JournalNeurochem Int
PubMed ID19154770
Ubiquitin (Ub) carboxy terminal hydrolase (UCH)-L1 and UCH-L3 are two of the deubiquitinating enzymes expressed in the brain. Both gad mice, which lack UCH-L1 expression and Uchl3 knockout mice exhibit neurodegeneration, although at distinct areas. These phenotypes indicate the importance of UCH-L1 and UCH-L3 in the regulation of the central ... More
The region-specific functions of two ubiquitin C-terminal hydrolase isozymes along the epididymis.
AuthorsKwon J, Sekiguchi S, Wang YL, Setsuie R, Yoshikawa Y, Wada K
JournalExp Anim
PubMed ID16508210
We previously showed that gad mice, which are deficient for ubiquitin C-terminal hydrolase L1 (UCH-L1), have a significantly increased number of defective spermatozoa, suggesting that UCH-L1 functions in sperm quality control during epididymal maturation. The epididymis is the site of spermatozoa maturation, transport and storage. Region-specific functions along the epididymis ... More