Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: role of nuclear factor-kappaB and activating protein-1.
'Vascular endothelial growth factor (VEGF) and interleukin-8/CXCL8 (IL-8) are prominent pro-angiogenic and pro-metastatic proteins that represent negative prognostic factors in many types of cancer. Hypoxia is thought to be the primary environmental cause of VEGF and IL-8 expression in solid tumors. We hypothesized that a lack of nutrients other than ... More
Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB.
AuthorsBrown RC, Mark KS, Egleton RD, Huber JD, Burroughs AR, Davis TP,
JournalJ Cell Sci
PubMed ID12538770
'Co-culture with glial cells and glia-conditioned media can induce blood-brain barrier properties in microvessel endothelial cells and protect against hypoxia-induced blood-brain barrier breakdown. We examined the effect of two types of glia-conditioned media on brain microvessel endothelial cell permeability and tight junction protein expression, and studied potential mechanisms of action. ... More
PKC zeta participates in activation of inflammatory response induced by enteropathogenic E. coli.
AuthorsSavkovic SD, Koutsouris A, Hecht G,
JournalAm J Physiol Cell Physiol
PubMed ID12900386
'We showed previously that enteropathogenic Escherichia coli (EPEC) infection of intestinal epithelial cells induces inflammation by activating NF-kappa B and upregulating IL-8 expression. We also reported that extracellular signal-regulated kinases (ERKs) participate in EPEC-induced NF-kappa B activation but that other signaling molecules such as PKC zeta may be involved. The ... More
NF-kappa B in the vascular progression of melanoma.
AuthorsKashani-Sabet M, Shaikh L, Miller JR, Nosrati M, Ferreira CM, Debs RJ, Sagebiel RW,
JournalJ Clin Oncol
PubMed ID14966085
To examine a model of melanoma progression based on vascular factors and the role of NF-kappa B in the vascular progression of melanoma. A data set of 526 patients from the University of California San Francisco Melanoma Center with 2 years of follow-up or first relapse was studied. The impact ... More