Astrocytes in culture produce anandamide and other acylethanolamides.
Authors Walter Lisa; Franklin Allyn; Witting Anke; Moller Thomas; Stella Nephi;
JournalJ Biol Chem
PubMed ID11916961
'Anandamide (arachidonylethanolamide) is an endocannabinoid that belongs to the acylethanolamide lipid family. It is produced by neurons in a calcium-dependent manner and acts through cannabinoid CB1 receptors. Other members of the acylethanolamide lipid family are also produced by neurons and act through G-protein-coupled receptors: homo-gamma-linolenylethanolamide (HEA) and docosatetraenylethanolamide (DEA) act ... More
Contact and encirclement of glioma cells in vitro is an intrinsic behavior of a clonal human neural stem cell line.
AuthorsKhosh N, Brown CE, Aboody KS, Barish ME
JournalPLoS One
PubMed ID23240066
Pathotropic neural stem and/or progenitor cells (NSCs) can potentially deliver therapeutic agents to otherwise inaccessible cancers. In glioma, NSCs are found in close contact with tumor cells, raising the possibility that specificity of NSC contact with glioma targets originates in the tumor cells themselves. Alternatively, target preferences may originate, at ... More