Ginkgo biloba extract (Egb 761) inhibits beta-amyloid production by lowering free cholesterol levels.
AuthorsYao ZX, Han Z, Drieu K, Papadopoulos V,
JournalJ Nutr Biochem
PubMed ID15607648
'Ginkgo biloba extract (EGb 761) can improve cognitive function in patients with Alzheimer''s disease, but the molecular mechanisms underlying this effect remain undefined. Because free cholesterol may be involved in the production of beta-amyloid precursor protein and amyloid beta-peptide, key events in the development of Alzheimer''s disease, we examined EGb ... More
The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.
AuthorsCam JA, Zerbinatti CV, Knisely JM, Hecimovic S, Li Y, Bu G,
JournalJ Biol Chem
PubMed ID15126508
'The low density lipoprotein (LDL) receptor-related protein 1B (LRP1B) is a newly identified member of the LDL receptor family that shares high homology with the LDL receptor-related protein (LRP). LRP1B was originally described as a putative tumor suppressor in lung cancer cells; however, its expression profile in several regions of ... More
Fast anterograde transport of herpes simplex virus: role for the amyloid precursor protein of alzheimer's disease.
AuthorsSatpute-Krishnan P, DeGiorgis JA, Bearer EL,
JournalAging Cell
PubMed ID14677633
'Anterograde transport of herpes simplex virus (HSV) from its site of synthesis in the neuronal cell body out the neuronal process to the mucosal membrane is crucial for transmission of the virus from one person to another, yet the molecular mechanism is not known. By injecting GFP-labeled HSV into the ... More
Sporadic inclusion body myositis correlates with increased expression and cross-linking by transglutaminases 1 and 2.
AuthorsChoi YC, Park GT, Kim TS, Sunwoo IN, Steinert PM, Kim SY,
JournalJ Biol Chem
PubMed ID10722712
'Sporadic inclusion body myositis (SIBM) is characterized by vacuolar degeneration of muscle fibers and intrafiber clusters of paired helical filaments with abnormal amyloid deposition. Because of their potential involvement in other degenerative disorders, we have examined the expression of transglutaminases (TGases) in normal and SIBM tissues. We report that at ... More
The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites.
AuthorsMuresan V, Varvel NH, Lamb BT, Muresan Z,
JournalJ Neurosci
PubMed ID19295161
'The amyloid-beta (Abeta) precursor protein (APP), a transmembrane protein that undergoes proteolytic cleavage into defined fragments, has been implicated in axonal transport. The proposed role of APP as a vesicle receptor for the microtubule motor kinesin-1 has relevance for the pathogenesis of Alzheimer''s disease. Nevertheless, this function, which relies on ... More
Small-molecule inducers of Aß-42 peptide production share a common mechanism of action.
AuthorsBettayeb K, Oumata N, Zhang Y, Luo W, Bustos V, Galons H, Greengard P, Meijer L, Flajolet M,
JournalFASEB J
PubMed ID22972917
'The pathways leading specifically to the toxic Aß42 peptide production, a key event in Alzheimer''s disease (AD), are unknown. While searching for pathways that mediate pathological increases of Aß42, we identified Aftin-4, a new compound that selectively and potently increases Aß42 compared to DMSO (N2a cells: 7-fold; primary neurons: 4-fold; ... More
Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.
AuthorsGhersi E, Noviello C, D'Adamio L,
JournalJ Biol Chem
PubMed ID15347684
The amyloid-beta protein precursor (AbetaPP) is a type I transmembrane molecule that undergoes several finely regulated cleavage events. The physiopathological relevance of AbetaPP derives from the fact that its aberrant processing strongly correlates with the onset of Alzheimer's disease (AD). AD is a neurodegenerative disorder characterized by neuronal cell death, ... More
Antibodies to the C-terminus of the beta-amyloid precursor protein (APP): a site specific marker for the detection of traumatic axonal injury.
AuthorsStone JR, Singleton RH, Povlishock JT,
JournalBrain Res
PubMed ID10899295
Antibodies to the amyloid precursor protein (APP) are commonly used to detect traumatic axonal injury (TAI). Carried by fast anterograde axoplasmic transport, APP will pool at regions of impaired transport associated with TAI. Based primarily upon commercial antibody availability, previous studies have targeted the N-terminus of APP, which, with respect ... More
Reversal of fragile X phenotypes by manipulation of AßPP/Aß levels in Fmr1KO mice.
AuthorsWestmark CJ, Westmark PR, O'Riordan KJ, Ray BC, Hervey CM, Salamat MS, Abozeid SH, Stein KM, Stodola LA, Tranfaglia M, Burger C, Berry-Kravis EM, Malter JS,
JournalPLoS One
PubMed ID22046307
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading known genetic cause of autism. Fragile X mental retardation protein (FMRP), which is absent or expressed at substantially reduced levels in FXS, binds to and controls the postsynaptic translation of amyloid ß-protein precursor (AßPP) ... More