Transcription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in regulation of gland morphogenesis and regeneration.
AuthorsVoronov D, Gromova A, Liu D, Zoukhri D, Medvinsky A, Meech R, Makarenkova HP,
JournalInvest Ophthalmol Vis Sci
PubMed ID23532528
Lacrimal gland (LG) morphogenesis and repair are regulated by a complex interplay of intrinsic factors (e.g., transcription factors) and extrinsic signals (e.g., soluble growth/signaling factors). Many of these interconnections remain poorly characterized. Runt-related (Runx) factors belong to a small family of heterodimeric transcription factors known to regulate lineage-specific proliferation and ... More