Tissue-specific positive feedback requirements for production of type I interferon following virus infection.
AuthorsPrakash A, Smith E, Lee CK, Levy DE,
JournalJ Biol Chem
PubMed ID15767254
Type I interferon (IFN) is synthesized by most nucleated cells following viral infection. Robust IFN production in cell culture requires positive feedback expression of inducible signaling components, such as the transcription factor IRF7. However, the role of positive feedback and IRF7 in vivo may be more complex. We found that ... More
Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding.
AuthorsCaillaud A, Prakash A, Smith E, Masumi A, Hovanessian AG, Levy DE, Marié I,
JournalJ Biol Chem
PubMed ID12374802
Interferon regulatory factor 7 (IRF7) is an interferon-inducible transcription factor required for induction of delayed early interferon alpha genes and the onset of a potent antiviral state. After induction of IRF7 by autocrine interferon, latent IRF7 is activated by virus-induced phosphorylation on serine residues within the C-terminal regulatory domain. Although ... More