The rearrangement of filamentous actin in mossy fiber synapses in pentylenetetrazol-kindled C57BL/6 mice.
AuthorsZhang YF, Li SL, Xiong TQ, Yang LB, Li YN, Tan BH, Liu Q, Li YC,
Journal
PubMed ID24275550
'Chemical kindling, as an experimental model of epileptogenesis, is induced by repetitive administration of subconvulsive amount of excitatory drugs. Kindled mice do not typically display spontaneous recurrent seizures, but are instead characterized by enhanced seizure susceptibility to convulsive stimulations. In order to provide insights into the aberrant synaptic plasticity during ... More
Neuroadaptive changes in cerebellar neurons induced by chronic exposure to IL-6.
AuthorsGruol DL, Puro A, Hao C, Blakely P, Janneke E, Vo K,
JournalJ Neuroimmunol
PubMed ID21890220
IL-6 is an important signaling molecule in the CNS. CNS neurons express IL-6 receptors and their signal transduction molecules, consistent with a role for IL-6 in neuronal physiology. Research indicates that IL-6 levels are low in the normal brain but can be significantly elevated in CNS injury and disease. Relatively ... More
Altered hippocampal synaptic transmission in transgenic mice with astrocyte-targeted enhanced CCL2 expression.
Elevated expression of neuroinflammatory factors in the central nervous system (CNS) contributes to the cognitive impairment in CNS disorders such as injury, disease and neurodegenerative disorders. However, information on the role of specific neuroimmune factors in normal and abnormal CNS function is limited. In this study, we investigated the effects ... More