The role of signal transducer and activator of transcription 5 in the inhibitory effects of GH on adipocyte differentiation.
AuthorsRichter HE, Albrektsen T, Billestrup N,
JournalJ Mol Endocrinol
PubMed ID12683938
'GH inhibits primary rat preadipocyte differentiation and expression of late genes required for terminal differentiation. Here we show that GH-mediated inhibition of fatty acid-binding protein aP2 gene expression correlates with the activation of the Janus kinase-2/signal transducer and activator of transcription (STAT)-5 signalling pathway. Within minutes of treatment, GH induced ... More