Determinants of specificity of a baculovirus-expressed antibody Fab fragment that binds selectively to the activated form of integrin alpha IIb beta 3.
AuthorsAbrams C, Deng YJ, Steiner B, O'Toole T, Shattil SJ,
JournalJ Biol Chem
PubMed ID7518445
'PAC1 is an IgM kappa murine monoclonal antibody that, like the Arg-Gly-Asp-containing ligand fibrinogen, binds to integrin alpha IIb beta 3 only on activated platelets. The unique binding properties of PAC1 may be determined by its large size, its multivalency, and by variable region sequences, including an Arg-Tyr-Asp at residues ... More
IL-6 promotes cardiac graft rejection mediated by CD4+ cells.
AuthorsBooth AJ, Grabauskiene S, Wood SC, Lu G, Burrell BE, Bishop DK
JournalJ Immunol
PubMed ID22025555
IL-6 mediates numerous immunologic effects relevant to transplant rejection; however, its specific contributions to these processes are not fully understood. To this end, we neutralized IL-6 in settings of acute cardiac allograft rejection associated with either CD8(+) or CD4(+) cell-dominant responses. In a setting of CD8(+) cell-dominant graft rejection, IL-6 ... More