Layer positioning of late-born cortical interneurons is dependent on Reelin but not p35 signaling.
AuthorsHammond V, So E, Gunnersen J, Valcanis H, Kalloniatis M, Tan SS,
JournalJ Neurosci
PubMed ID16452688
'We tested the response of interneurons to the absence of Reelin signaling or p35 in the mouse neocortex. We provide three independent strands of evidence to demonstrate that layering of late-born (but not early-born) interneurons is regulated by Reelin signaling. First, early-born and late-born interneurons behaved differently in mice lacking ... More
PSD-95 assembles a ternary complex with the N-methyl-D-aspartic acid receptor and a bivalent neuronal NO synthase PDZ domain.
'Nitric oxide (NO) biosynthesis in cerebellum is preferentially activated by calcium influx through N-methyl-D-aspartate (NMDA)-type glutamate receptors, suggesting that there is a specific link between these receptors and neuronal NO synthase (nNOS). Here, we find that PSD-95 assembles a postsynaptic protein complex containing nNOS and NMDA receptors. Formation of this ... More
Analysis of the cytosolic proteome in a cell culture model of familial amyotrophic lateral sclerosis reveals alterations to the proteasome, antioxidant defenses, and nitric oxide synthetic pathways.
'Injury to motor neurons associated with mutant Cu,Zn-superoxide dismutase (SOD1)-related familial amyotrophic lateral sclerosis (FALS) results from a toxic gain-of-function of the enzyme. The mechanisms by which alterations to SOD1 elicit neuronal death remain uncertain despite intensive research effort. Analysis of the cellular proteins that are differentially expressed in the ... More
Tetrahydrobiopterin deficiency induces gastroparesis in newborn mice.
AuthorsWelsh C, Enomoto M, Pan J, Shifrin Y, Belik J,
JournalAm J Physiol Gastrointest Liver Physiol
PubMed ID23639814
Pyloric stenosis, the most common infant gastrointestinal disease, has no known etiology and clinically presents as abnormal gastric emptying with evidence of pyloric muscle hypertrophy. Whether abnormalities in gastric muscle contraction and/or relaxation have a role in this condition is poorly known, but gastroparesis is commonly observed in association with ... More
Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia.
AuthorsLittler CM, Wehling CA, Wick MJ, Fagan KA, Cool CD, Messing RO, Dempsey EC,
JournalAm J Physiol Lung Cell Mol Physiol
PubMed ID16085670
Loss of PKC-epsilon limits the magnitude of acute hypoxic pulmonary vasoconstriction (HPV) in the mouse. Therefore, we hypothesized that loss of PKC-epsilon would decrease the contractile and/or structural response of the murine pulmonary circulation to chronic hypoxia (Hx). However, the pattern of lung vascular responses to chronic Hx may or ... More
Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice.
AuthorsChakkalakal JV, Harrison MA, Carbonetto S, Chin E, Michel RN, Jasmin BJ,
JournalHum Mol Genet
PubMed ID14681302
Utrophin has been studied extensively in recent years in an effort to find a cure for Duchenne muscular dystrophy. In this context, we previously showed that mice expressing enhanced muscle calcineurin activity (CnA*) displayed elevated levels of utrophin around their sarcolemma. In the present study, we therefore crossed CnA* mice ... More
Distribution of soluble guanylyl cyclase in rat retina.
AuthorsDing JD, Weinberg RJ
JournalJ Comp Neurol
PubMed ID17436468
The nitric oxide (NO)-cGMP pathway is implicated in modulation of visual information processing in the retina. Despite numerous functional studies of this pathway, information about the retinal distribution of the major downstream effector of NO, soluble guanylyl cyclase (sGC), is very limited. In the present work, we have used immunohistochemistry ... More
Nitric oxide signaling modulates synaptic transmission during early postnatal development.
AuthorsCserép C, Szonyi A, Veres JM, Németh B, Szabadits E, de Vente J, Hájos N, Freund TF, Nyiri G
JournalCereb Cortex
PubMed ID21282319
Early ?-aminobutyric acid mediated (GABAergic) synaptic transmission and correlated neuronal activity are fundamental to network formation; however, their regulation during early postnatal development is poorly understood. Nitric oxide (NO) is an important retrograde messenger at glutamatergic synapses, and it was recently shown to play an important role also at GABAergic ... More
Neurturin regulates postnatal differentiation of parasympathetic pelvic ganglion neurons, initial axonal projections, and maintenance of terminal fields in male urogenital organs.
AuthorsYan H, Keast JR
JournalJ Comp Neurol
PubMed ID18175352
We have investigated the development of autonomic nerves in the urogenital tract of male mice and the effect of neurturin gene deletion on this process. At birth, autonomic innervation of the reproductive organs was sparse, but urinary bladder smooth muscle was well innervated. Further innervation of reproductive tissues occurred until ... More
Expression of receptors for glial cell line-derived neurotrophic factor family ligands in sacral spinal cord reveals separate targets of pelvic afferent fibers.
AuthorsForrest SL, Keast JR
JournalJ Comp Neurol
PubMed ID18085594
Nerve growth factor has been proposed to mediate many structural and chemical changes in bladder sensory neurons after injury or inflammation. We have examined the expression of receptors for the glial cell line-derived neurotrophic factor (GDNF) family within sensory terminals located in the sacral spinal cord and in bladder-projecting sacral ... More