Neuronal fodrin proteolysis occurs independently of excitatory amino acid-induced neurotoxicity.
AuthorsDi Stasi AM, Gallo V, Ceccarini M, Petrucci TC
JournalNeuron
PubMed ID1848081
In cultured cerebellar granule cells, the total amount of fodrin alpha subunit increased 3-fold between 0 and 10 days in vitro and fodrin mRNA increased 5-fold. The exposure of cerebellar neurons to NMDA induced the accumulation of a 150 kd proteolytic fragment of fodrin. The NMDA-induced breakdown of fodrin was ... More
Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-beta-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: an in vivo study using an androgen suppression model.
AuthorsZhang J, Wong CH, Xia W, Mruk DD, Lee NP, Lee WM, Cheng CY
JournalEndocrinology
PubMed ID15591133
Using a well characterized model of cell-cell actin-based adherens junction (AJ) disruption by suppressing the intratesticular testosterone level in adult rats with testosterone-estradiol implants, we have confirmed earlier findings that Sertoli-germ cell AJ dynamics are regulated by the activation of kinases via putative signaling pathways but with some unexpected findings ... More