Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations.
AuthorsLinton PJ L, Decker DJ, Klinman NR
JournalCell
PubMed ID2598260
Two precursor cell subpopulations have been isolated from the spleen cells of nonimmune mice. The major B cell subpopulation binds high levels of the J11D monoclonal antibody and, upon T cell-dependent antigenic stimulation, gives rise to primary antibody-forming cell clones but not secondary B cells. A minority of the 10%-14% ... More