Dynabeads™ MyOne™ Streptavidin T1, 2 mL

Dynabeads™ MyOne™ Streptavidin T1, 2 mL - Citations

View additional product information for Dynabeads™ Streptavidin Magnetic Beads - Citations (65604D, 65801D, 65605D, 65002, 65001, 65602, 65305, 65601, 11205D, 11206D, 65306, 65606D, 65607D, 60101, 60210)

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Citations & References

Abstract

Quantification of ricin, RCA and comparison of enzymatic activity in 18 Ricinus communis cultivars by isotope dilution mass spectrometry.

AuthorsSchieltz DM, McWilliams LG, Kuklenyik Z, Prezioso SM, Carter AJ, Williamson YM, McGrath SC, Morse SA, Barr JR

Journal

PubMed ID25576235

'The seeds of the Ricinus communis (Castor bean) plant are the source of the economically important commodity castor oil. Castor seeds also contain the proteins ricin and R. communis agglutinin (RCA), two toxic lectins that are hazardous to human health. Radial immunodiffusion (RID) and the enzyme linked immunosorbent assay (ELISA) ... More

Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets.

AuthorsClinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS

Journal

PubMed ID25287718

'Ebolaviruses are highly lethal filoviruses that cause hemorrhagic fever in humans and nonhuman primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent global health need. Here, we describe the design, biophysical characterization, and validation of ... More

Minimalistic sample preparation strategies for LC-MS quantification of large molecule biopharmaceuticals: a case study highlighting alpha-1 antitrypsin protein.

AuthorsWright K, Dufield D

Journal

PubMed ID25157487

Large molecule biotherapeutics pose a distinctive bioanalytical challenge for LC-MS assay development, particularly when optimizing sample enrichment steps. Alpha-1 antitrypsin (AAT) is used as an example for highlighting large-molecule assay-development strategies. ... More

A U1 snRNP-specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange.

AuthorsSo BR, Wan L, Zhang Z, Li P, Babiash E, Duan J, Younis I, Dreyfuss G

JournalNat Struct Mol Biol

PubMed ID26828962

Despite equal snRNP stoichiometry in spliceosomes, U1 snRNP (U1) is typically the most abundant vertebrate snRNP. Mechanisms regulating U1 overabundance and snRNP repertoire are unknown. In Sm-core assembly, a key snRNP-biogenesis step mediated by the SMN complex, the snRNA-specific RNA-binding protein (RBP) Gemin5 delivers pre-snRNAs, which join SMN-Gemin2-recruited Sm proteins. ... More