PKC-? exists in an oxidized inactive form in naive human T cells.
Authorsvon Essen MR, Kongsbak M, Levring TB, Hansen AK, Boding L, Lauritsen JP, Woetmann A, Baier G, Ødum N, Bonefeld CM, Geisler C,
JournalEur J Immunol
PubMed ID23436678
PKC-? plays a central role in TCR-induced IL-2 production and T-cell proliferation. The aim of the present study was to analyse how PKC-? is regulated in human T cells during T-cell activation and differentiation. We show that PKC-? is found in a high-molecular disulfide-linked complex in naïve T cells, and ... More