Quantitative differences in CD45 expression unmask functions for CD45 in B-cell development, tolerance, and survival.
AuthorsZikherman J, Doan K, Parameswaran R, Raschke W, Weiss A
JournalProc Natl Acad Sci U S A
PubMed ID22135465
'The receptor-like tyrosine phosphatase CD45 positively regulates antigen receptor signaling by dephosphorylating the inhibitory tyrosine of the src family kinases. CD45-deficient mice fail to fully unmask the role of CD45 in B cells because of the expression of a partially redundant tyrosine phosphatase, CD148. However, mice that are doubly deficient ... More