Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependent.
AuthorsZaman G, Sunters A, Galea GL, Javaheri B, Saxon LK, Moustafa A, Armstrong VJ, Price JS, Lanyon LE
JournalJ Biol Chem
PubMed ID22049075
Of the 1,328 genes revealed by microarray to be differentially regulated by disuse, or at 8 h following a single short period of osteogenic loading of the mouse tibia, analysis by predicting associated transcription factors from annotated affinities revealed the transcription factor EGR2/Krox-20 as being more closely associated with more ... More