Evaluation of dimerization-inhibitory activities of cyclic peptides containing a ß-hairpin loop sequence of the EGF receptor.
AuthorsMizuguchi T, Ohara N, Iida M, Ninomiya R, Wada S, Kiso Y, Saito K, Akaji K,
JournalBioorg Med Chem
PubMed ID22959765
Structure-activity relationships of cyclic peptides mimicking the ß-hairpin structure of the 'dimerization arm' at residues 242-259 of the EGF receptor are examined. Cyclic peptides containing the arm head of the ß-hairpin loop showed inhibitory activity toward the EGF receptor's dimerization. Cyclic peptides containing a Retro-Inverso sequence of the dimerization arm ... More