Label-free recognition of drug resistance via impedimetric screening of breast cancer cells.
AuthorsEker B, Meissner R, Bertsch A, Mehta K, Renaud P,
JournalPLoS One
PubMed ID23483910
We present a novel study on label-free recognition and distinction of drug resistant breast cancer cells (MCF-7 DOX) from their parental cells (MCF-7 WT) via impedimetric measurements. Drug resistant cells exhibited significant differences in their dielectric properties compared to wild-type cells, exerting much higher extracellular resistance (Rextra ). Immunostaining revealed ... More
Distinguishing drug-induced minor morphological changes from major cellular damage via label-free impedimetric toxicity screening.
AuthorsMeissner R, Eker B, Kasi H, Bertsch A, Renaud P,
JournalLab Chip
PubMed ID21647498
We present a novel perfusion-based microfluidic platform for label-free drug toxicity screening which can single out non-lethal morphological changes from cellular death using electrical impedance spectroscopy. Minor cellular changes such as cell-cell contacts and major cell injury were identified via impedance phase angle analysis and follow-up of impedance magnitude at ... More
Claudin 1 expression characterizes human uterine cervical reserve cells.
AuthorsZinner B, Gyöngyösi B, Babarczi E, Kiss A, Sobel G,
Journal
PubMed ID23900598
Stem cells participate in cervical carcinogenesis but their function and exact features are still not clear. One type of stem-like cells are endocervical reserve cells (RCs), and their association with other normal/altered cervical cells is not exactly known. Epithelial cells are attached to each other by tight junctions. Their dominant ... More