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Invitrogen

CX3CR1 Recombinant Rabbit Monoclonal Antibody (1H14L7)

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View all (33) CX3CR1 antibodies

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CX3CR1 Recombinant Rabbit Monoclonal Antibody (1H14L7)

Product Details

702321

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (IHC)

-
View 2 publications 2 publications

Immunohistochemistry (Frozen) (IHC (F))

-
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

2 µg/mL
View 3 publications 3 publications
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Expression System

Expi293

Class

Recombinant Monoclonal

Type

Antibody

Clone

1H14L7

Immunogen

Peptides corresponding to human CX3CR1 (aa6-19, 339-351)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2662897

Product Specific Information

This antibody is predicted to react with Monkey, Dog, Cat

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Target Information

CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration an d adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Beta chemokine receptor-like 1; C-X3-C CKR-1; chemokine (C-C) receptor-like 1; chemokine (C-X3-C motif) receptor 1; chemokine (C-X3-C) receptor 1; CMK-BRL-1; CMK-BRL1; Cx3c; CX3C chemokine receptor 1; Fractalkine receptor; G-protein coupled receptor 13; Scyd1; unnamed protein product; V28

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Gene Aliases: CCRL1; CMKBRL1; CMKDR1; CX3CR1; GPR13; GPRV28; Rbs11; V28

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UniProt ID: (Human) P49238, (Rat) P35411, (Mouse) Q9Z0D9

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Entrez Gene ID: (Human) 1524, (Rat) 171056, (Mouse) 13051

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Function(s)
cytokine receptor activity G-protein coupled receptor activity chemokine receptor activity protein binding G-protein coupled peptide receptor activity C-C chemokine receptor activity C-X3-C chemokine receptor activity C-C chemokine binding C-X3-C chemokine binding CX3C chemokine receptor binding signal transducer activity
Process(es)
positive regulation of neuroblast proliferation adaptive immune response microglial cell activation involved in immune response immune system process response to ischemia chemotaxis inflammatory response immune response cellular defense response cell adhesion signal transduction cell surface receptor signaling pathway G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration cell-cell signaling brain development response to wounding negative regulation of angiogenesis cytokine-mediated signaling pathway calcium-mediated signaling central nervous system maturation leukocyte chemotaxis regulation of tumor necrosis factor production negative regulation of interleukin-1 beta production social behavior autocrine signaling positive regulation of I-kappaB kinase/NF-kappaB signaling innate immune response regulation of nitric oxide biosynthetic process regulation of synaptic plasticity host-mediated regulation of intestinal microbiota composition regulation of neurogenesis positive regulation of neurogenesis modulation of synaptic transmission leukocyte tethering or rolling positive regulation of protein kinase B signaling synapse maturation cell chemotaxis antifungal innate immune response chemokine-mediated signaling pathway cellular response to lipopolysaccharide cellular response to cytokine stimulus positive regulation of monocyte chemotaxis synapse pruning negative regulation of hippocampal neuron apoptotic process multiple spine synapse organization, single dendrite regulation of microglial cell migration negative regulation of microglial cell mediated cytotoxicity negative regulation of apoptotic signaling pathway microglial cell activation negative regulation of chronic inflammatory response to non-antigenic stimulus memory cerebral cortex cell migration negative regulation of cell migration positive regulation of angiogenesis macrophage chemotaxis cellular response to transforming growth factor beta stimulus negative regulation of long-term synaptic potentiation negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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