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Invitrogen
NME1 Recombinant Rabbit Monoclonal Antibody (11H2L6)
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图: 1 / 4
NME1 Antibody (702425) in ICC/IF
For immunofluorescence analysis, SK-OV-3 cells were fixed and permeabilized for detection of endogenous NME1 using NME1 Recombinant Rabbit Monoclonal Antibody (Product # 702425, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of NME1 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Pa... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
702425
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
11H2L6
抗原
Protein corresponding to Human NME1 (aa 1-152)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Rat, Pig and Bovine.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
NME1 was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in the gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: expressed in non-metastatic cells 1 protein; expressed in non-metastatic cells 1, protein; Farnesyl diphosphate kinase NME1; GAAD; Granzyme A activated DNase (GAAD); GZMA activated DNase; Histidine protein kinase NDK; Histidine protein kinase NME1; included; Metastasis inhibition factor NM23; NDK A; NDK1; NDP kinase A; NDPK-A; NM23-H1; nm23-M1; NM23H1B; NME1-NME2 spliced read-through transcript; non-metastatic cells 1, protein (NM23A) expressed in; Non-specific serine/threonine protein kinase NME1; Nucleoside diphoshate kinase 1; Nucleoside diphosphate kinase A; nucleoside-diphosphate kinase 1; nucleotide diphosphate kinase; Putative 3'-5'-DNA exonuclease NDK1; Putative granzyme A-activated DNA endonuclease; Tumor metastatic process-associated protein
基因别名: AL024257; NDPK-A; NDPKA; NM23; NM23-M1; NM23A; NME1
UniProt ID: (Mouse) P15532
Entrez Gene ID: (Mouse) 18102
nucleotide binding
magnesium ion binding
RNA polymerase II regulatory region sequence-specific DNA binding
single-stranded DNA binding
deoxyribonuclease activity
nucleoside diphosphate kinase activity
ATP binding
GTP binding
kinase activity
transferase activity
intermediate filament binding
enzyme binding
protein kinase binding
identical protein binding
gamma-tubulin binding
ribosomal small subunit binding
poly(A) RNA binding
metal ion binding
kinase
negative regulation of myeloid leukocyte differentiation
purine nucleotide metabolic process
nucleoside diphosphate phosphorylation
GTP biosynthetic process
pyrimidine nucleotide metabolic process
UTP biosynthetic process
CTP biosynthetic process
DNA metabolic process
endocytosis
nervous system development
lactation
nucleotide metabolic process
nucleoside triphosphate biosynthetic process
negative regulation of gene expression
positive regulation of neuron projection development
phosphorylation
cell differentiation
mammary gland development
regulation of apoptotic process
positive regulation of DNA binding
positive regulation of epithelial cell proliferation
nucleic acid phosphodiester bond hydrolysis
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
